- Clinical Features and Risk Factors of Post-COVID-19 Condition in Korea
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Myungwon Jang, Dongkwon Choi, Jonghyuk Choi, Ho-Jang Kwon
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J Prev Med Public Health. 2023;56(5):431-439. Published online September 8, 2023
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DOI: https://doi.org/10.3961/jpmph.23.124
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 Abstract
Summary
 PDF Supplementary Material
- Objectives
Numerous studies have explored the causes and spread of outbreaks, yet there is a lack of research on post-coronavirus disease 2019 condition (PCC) in Korea. The goal of this study was to identify the various types of PCC and associated factors in discharged patients and to provide directions for the ongoing health management of confirmed patients.
Methods
A telephone survey was conducted among 680 coronavirus disease 2019 (COVID-19) patients diagnosed between July 7, 2021 and August 26, 2021, in Dangjin, Chungnam, Korea. A descriptive analysis of characteristics, univariate analysis, and regression were performed using data from basic epidemiological surveys conducted at the time of diagnosis and post-discharge questionnaires.
Results
Of the 585 patients who responded, 159 (27.2%) developed PCC. Of the 211 patients with no initial symptoms, 27 (12.8%) developed PCC, versus 132 (35.3%) of the 374 patients with initial symptoms. Among the initial symptoms, fever or chills, cough or sputum, loss of smell, and sore throat were associated with PCC. Compared to patients with less than 10 days of hospitalization, those with a hospitalization period of 21 days to 30 days (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.0 to 5.2) and 31 days or more (OR, 5.8; 95% CI, 1.9 to 18.1) had a higher risk of PCC.
Conclusions
More than a quarter of COVID-19 patients, including those who had no initial symptoms, experienced PCC in Korea. People with the initial symptoms of fever, chills, and respiratory symptoms and those who had prolonged hospital stays had a high risk of PCC.
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Summary
Korean summary
코로나19 후유증은 진단 시 초기증상과 연관되며, 입원기간이 길어질수록 후유증 발병 위험이 높았다. 코로나19 후유증의 위험인자에 대한 추가적인 연구가 필요하며, 이러한 특징을 갖는 확진환자를 대상으로 퇴원 후 지속직인 환자관리가 필요하다.
Key Message
Post-coronavirus disease 2019 condition (PCC) are associated with initial symptoms at diagnosis, and the risk of this increases with longer hospital stays. Further research on the risk factors for PCC is needed, and continued patient care is necessary for confirmed patients with these characteristics after discharge.
- Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study
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Jonghyuk Choi, Sanghyuk Bae, Hyungryul Lim, Ji-Ae Lim, Yong-Han Lee, Mina Ha, Ho-Jang Kwon
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J Prev Med Public Health. 2017;50(6):377-385. Published online November 7, 2017
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DOI: https://doi.org/10.3961/jpmph.17.099
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Abstract
PDFSupplementary Material
- Objectives
Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated serum levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT).
Methods
We repeatedly examined the levels of total Hg and liver enzymes in the blood of 508 adults during 2010-2011 and 2014-2015. Cross-sectional associations between levels of blood Hg and liver enzymes were analyzed using a generalized linear model, and nonlinear relationships were analyzed using a generalized additive mixed model. Generalized estimating equations were applied to examine longitudinal associations, considering the correlations of individuals measured repeatedly.
Results
GGT increased by 11.0% (95% confidence interval [CI], 4.5 to 18.0%) in women and 8.1% (95% CI, -0.5 to 17.4%) in men per doubling of Hg levels, but AST and ALT were not significantly associated with Hg in either men or women. In women who drank more than 2 or 3 times per week, AST, ALT, and GGT levels increased by 10.6% (95% CI, 4.2 to 17.5%), 7.7% (95% CI, 1.1 to 14.7%), and 37.5% (95% CI,15.2 to 64.3%) per doubling of Hg levels, respectively, showing an interaction between blood Hg levels and drinking.
Conclusions
Hg exposure was associated with an elevated serum concentration of GGT. Especially in women who were frequent drinkers, AST, ALT, and GGT showed a significant increase, with a significant synergistic effect of Hg and alcohol consumption.
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Summary
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Citations
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